The KIX domain is a highly conserved independently folding three-helix bundle that provides two allosteric docking sites for transcription factors, whereupon promoter activation and target specificity are achieved during gene regulation. The targets of KIX are often intrinsically disordered regions within the trans-activation domains of transcription factors that attain stable secondary structure only upon complexation with KIX. KIXBASE is the global repository comprising the largest online collection of KIX sequences. It provides useful information about critical aspects of KIX domains such as their intrinsic disorder, hydrophobicity profiles, functional classification and annotation based on domain architectures.

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